Genetic Characteristics of Sickle Cell Anemia Bearing the Bantu
نویسندگان
چکیده
Previous work has demonstrated that the HbS gene has appeared and expanded three times in Africa in three separate geographic locations and that these three distinct mutational events can be identified by linked DNA polymorphic sites (haplotypes) surrounding the abnormal gene. We have reported that the Senegalese and Beninian haplotypes differ in G,., , expression. mean percentage of HbF. and percentage of dense cells. We now report on the third haplotype. the Bantu. and find that it has intermediate features. namely. the high mean percentage of HbF and low percentage of dense cells associated with the Senegalese haplotype. but with a low percentage of G expression similar to the Beninian haplotype. The distribution of
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